Improving sensitivity of autoantibody testing for myasthenia gravis using cell-based assays: an evaluation of strategies that may be used in clinical practice - Takeaways - MDSpire

Improving sensitivity of autoantibody testing for myasthenia gravis using cell-based assays: an evaluation of strategies that may be used in clinical practice

  • By

  • Adrian Budhram

  • Ola Z. Ismail

  • Kamala Sangam

  • Lulu L. C. D. Bursztyn

  • Ario Mirian

  • Yiu-Chia Chang

  • Michael W. Nicolle

  • July 3, 2026

  • 0 min

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  • 1

    The study evaluated strategies to enhance the sensitivity of autoantibody testing for myasthenia gravis using cell-based assays.

  • 2

    A total of 973 patients underwent anti-AChR/MuSK fixed CBA, with 127 (13.1%) showing autoantibody positivity during the evaluation period.

  • 3

    Repeat fixed CBA identified 4 positive cases (5%) among 78 patients who were initially negative for anti-AChR/MuSK.

  • 4

    Send-out live CBA detected autoantibodies in 4 out of 13 patients (31%) who had negative or indeterminable fixed CBA results.

  • 5

    Testing at a lower dilution of 1:5 revealed 50% positivity in samples that were negative at the 1:10 dilution.

Original Source(s)

Improving sensitivity of autoantibody testing for myasthenia gravis using cell-based assays: an evaluation of strategies that may be used in clinical practice

  • by Adrian Budhram, Ola Z. Ismail, Kamala Sangam, Lulu L. C. D. Bursztyn, Ario Mirian, Yiu-Chia Chang, Michael W. Nicolle

  • July 3, 2026

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