Vaginal dysbiosis and inflammatory signatures in preterm labor: an integrated model for predicting preterm birth - Takeaways - MDSpire

Vaginal dysbiosis and inflammatory signatures in preterm labor: an integrated model for predicting preterm birth

  • By

  • Subeen Hong

  • Gi Soo Um

  • Byung Soo Kang

  • Oyoung Kim

  • Seon Ui Lee

  • Hyun Sun Ko

  • Sangho Nam

  • Seungok Lee

  • In Yang Park

  • Sun Shin

  • June 5, 2026

  • 0 min

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  • 1

    Preterm birth (PTB) is linked to vaginal microbiome dysbiosis and inflammatory responses, contributing to neonatal morbidity and mortality.

  • 2

    The study analyzed 136 pregnant women, categorizing them into Control, PTL-TB, and PTL-PTB groups to assess microbiome and immune factors.

  • 3

    Dysbiosis and community state type IV were more common in the PTL-PTB group, indicating a correlation with preterm birth risk.

  • 4

    MMP-9 levels were consistently elevated in PTL-PTB cases, suggesting its role in linking dysbiosis to extracellular matrix remodeling.

  • 5

    A logistic regression model incorporating microbiome and inflammatory markers showed excellent predictive performance for PTB.

Original Source(s)

Vaginal dysbiosis and inflammatory signatures in preterm labor: an integrated model for predicting preterm birth

  • by Subeen Hong, Gi Soo Um, Byung Soo Kang, Oyoung Kim, Seon Ui Lee, Hyun Sun Ko, Sangho Nam, Seungok Lee, In Yang Park, Sun Shin

  • June 5, 2026

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