Erythrocyte odd-chain fatty acids and the risk of cardiometabolic diseases: a prospective study and updated meta-analysis - Takeaways - MDSpire

Erythrocyte odd-chain fatty acids and the risk of cardiometabolic diseases: a prospective study and updated meta-analysis

  • By

  • Liang Sun

  • Xinming Xu

  • Huaidong Du

  • Ling Lu

  • Fumiaki Imamura

  • Qishan Yang

  • Yiping Chen

  • Yan Chen

  • Pei Pei

  • Huiyong Yin

  • Ling Yang

  • Geng Zong

  • Canqing Yu

  • Qianqian Chu

  • Jun Lv

  • Puchen Zhou

  • Dianjianyi Sun

  • Junshi Chen

  • Xiang Gao

  • Liming Li

  • Zhengming Chen

  • Xu Lin

  • on behalf of the China Kadoorie Biobank Collaborative Group

  • September 24, 2025

  • 0 min

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  • 1

    Erythrocyte odd-chain fatty acids (OCFAs) 15:0 and 17:0 are inversely associated with cardiometabolic diseases (CMDs) in a Chinese population.

  • 2

    Higher levels of 15:0 and 17:0 correlate with dietary intake of dairy, fish, and whole grains, suggesting diverse dietary sources of OCFAs.

  • 3

    The study recorded 950 incident CMDs over a 5-year follow-up, including ischemic heart disease, diabetes, and stroke.

  • 4

    Meta-analysis confirmed that OCFAs are associated with lower risks of diabetes and ischemic heart disease across various populations.

  • 5

    OCFAs may serve as modifiable biomarkers for nutritional assessment and could guide dietary interventions to reduce CMD risks.

Original Source(s)

Erythrocyte odd-chain fatty acids and the risk of cardiometabolic diseases: a prospective study and updated meta-analysis

  • by Liang Sun, Xinming Xu, Huaidong Du, Ling Lu, Fumiaki Imamura, Qishan Yang, Yiping Chen, Yan Chen, Pei Pei, Huiyong Yin, Ling Yang, Geng Zong, Canqing Yu, Qianqian Chu, Jun Lv, Puchen Zhou, Dianjianyi Sun, Junshi Chen, Xiang Gao, Liming Li, Zhengming Chen, Xu Lin, on behalf of the China Kadoorie Biobank Collaborative Group

  • September 24, 2025

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