Emergence of Acquired HIV Drug Resistance Among Individuals Receiving Dolutegravir-Based Antiretroviral Therapy in Uganda: A National Laboratory-Based Survey 2023 - Takeaways - MDSpire

Emergence of Acquired HIV Drug Resistance Among Individuals Receiving Dolutegravir-Based Antiretroviral Therapy in Uganda: A National Laboratory-Based Survey 2023

  • By

  • Juliet Nkugwa Asio

  • Christine Watera

  • Grace Namayanja

  • Juliana de Fatima da Silva

  • Sherri Pals

  • Deogratius Ssemwanga

  • Grace Sanyu

  • Maria Nannyonjo

  • Usher Kabuga Kaganda

  • Ronald Busobozi

  • Hellen Nansumba

  • Miriam Nabukenya

  • Alisen Ayitewala

  • Mina Ssali

  • Cordelia Katureebe

  • Eleanor Namusoke Magongo

  • Hudson Balidawa

  • Esther Nazziwa

  • Jonathan Ntale

  • Elliot Raizes

  • Du-Ping Zheng

  • Clement Zeh

  • Stephanie Hackett

  • Mary Naluguza

  • Edward Katongole Mbidde

  • Pontiano Kaleebu

  • November 6, 2025

  • 0 min

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  • 1

    The study found a 10.1% prevalence of dolutegravir resistance in children and 8.6% in adults, indicating an increase from previous years.

  • 2

    The survey analyzed 857 specimens from patients on dolutegravir-based regimens for at least 9 months with viral nonsuppression.

  • 3

    Resistance to dolutegravir is rising, emphasizing the need for improved adherence and early identification of at-risk individuals.

  • 4

    The study utilized the Cyclical Acquired HIV Drug Resistance methodology to monitor trends in HIV drug resistance in Uganda.

  • 5

    By March 2023, 97% of ART recipients in Uganda were on dolutegravir-based regimens, with viral load suppression exceeding 90%.

Original Source(s)

Emergence of Acquired HIV Drug Resistance Among Individuals Receiving Dolutegravir-Based Antiretroviral Therapy in Uganda: A National Laboratory-Based Survey 2023

  • by Juliet Nkugwa Asio, Christine Watera, Grace Namayanja, Juliana de Fatima da Silva, Sherri Pals, Deogratius Ssemwanga, Grace Sanyu, Maria Nannyonjo, Usher Kabuga Kaganda, Ronald Busobozi, Hellen Nansumba, Miriam Nabukenya, Alisen Ayitewala, Mina Ssali, Cordelia Katureebe, Eleanor Namusoke Magongo, Hudson Balidawa, Esther Nazziwa, Jonathan Ntale, Elliot Raizes, Du-Ping Zheng, Clement Zeh, Stephanie Hackett, Mary Naluguza, Edward Katongole Mbidde, Pontiano Kaleebu

  • November 6, 2025

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