Spreading depolarization triggers pro- and anti-inflammatory signalling: a potential link to headache - Takeaways - MDSpire

Spreading depolarization triggers pro- and anti-inflammatory signalling: a potential link to headache

  • By

  • Zeynep Kaya

  • Nevin Belder

  • Melike Sever-Bahcekapili

  • Şefik Evren Erdener

  • Buket Dönmez-Demir

  • Canan Bağcı

  • Merve Nur Köroğlu

  • Kaya Bilguvar

  • Turgay Dalkara

  • January 17, 2025

  • 0 min

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  • 1

    Cortical spreading depolarization (CSD) is linked to migraine headaches through inflammatory signaling from neurons to meninges via astrocytes.

  • 2

    Pro-inflammatory mechanisms in astrocytes transition to anti-inflammatory responses within 24 hours post-CSD, indicating a shift in inflammatory activity.

  • 3

    Microglia exhibit transcriptional changes towards an anti-inflammatory profile after CSD, suggesting their role in supporting astrocytic inflammatory responses.

  • 4

    CSD triggers the release of high mobility group box 1 and activation of caspase-1, initiating pro-inflammatory nuclear factor kappa B activation.

  • 5

    Understanding the inflammatory response in CNS cell types is crucial for elucidating the mechanisms behind headache initiation and resolution.

Original Source(s)

Spreading depolarization triggers pro- and anti-inflammatory signalling: a potential link to headache

  • by Zeynep Kaya, Nevin Belder, Melike Sever-Bahcekapili, Şefik Evren Erdener, Buket Dönmez-Demir, Canan Bağcı, Merve Nur Köroğlu, Kaya Bilguvar, Turgay Dalkara

  • January 17, 2025

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