A multi-mineral intervention is associated with improved intestinal permeability in patients with ulcerative colitis: results from a pilot trial

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Aquamin®, a multi-mineral extract from red marine algae, was tested for its effects on intestinal permeability in ulcerative colitis patients.
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The pilot study involved 16 participants, including 8 with mild ulcerative colitis and 8 healthy controls, over a 90-day period.
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Urinary mannitol excretion decreased significantly in UC patients after Aquamin® supplementation, indicating improved intestinal barrier function.
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Aquamin® supplementation resulted in a 29% reduction in total post-intervention mannitol excretion among UC patients.
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The study reported no serious adverse events, suggesting that Aquamin® was well tolerated among participants.

Frontiers In Medicine

by Muhammad N. Aslam, Danielle Kim Turgeon, Shannon McClintock, Ron Allen, Ananda Sen, James Varani
June 22, 2026

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