Assessment of hemoglobin-to-red cell distribution width ratio to predict all-cause mortality in patients with sepsis: a retrospective cohort study from the MIMIC-IV database - Takeaways - MDSpire

Assessment of hemoglobin-to-red cell distribution width ratio to predict all-cause mortality in patients with sepsis: a retrospective cohort study from the MIMIC-IV database

  • By

  • Zhiwei Su

  • Yin Wen

  • Wenhong Zhong

  • Hongguang Ding

  • Hongke Zeng

  • July 13, 2026

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  • 1

    The study analyzed 28,812 sepsis patients from the MIMIC-IV database to evaluate the Hemoglobin-to-Red Cell Distribution Width Ratio (HRR) as a mortality predictor.

  • 2

    High HRR scores correlated with lower 28-day mortality rates, with the high-score group showing a mortality rate of 20.23% compared to 25.72% in the low-score group.

  • 3

    Cox proportional hazards regression indicated that higher HRR significantly reduced the risk of 28-day mortality (HR, 0.73; 95% CI, 0.68–0.79) in the unmatched cohort.

  • 4

    A non-linear relationship was found between HRR and 28-day mortality, with a threshold of 0.78 identified as an inflection point for mortality risk.

  • 5

    Integrating HRR with existing disease severity scores may enhance predictive accuracy for 28-day mortality in sepsis patients.

Original Source(s)

Assessment of hemoglobin-to-red cell distribution width ratio to predict all-cause mortality in patients with sepsis: a retrospective cohort study from the MIMIC-IV database

  • by Zhiwei Su, Yin Wen, Wenhong Zhong, Hongguang Ding, Hongke Zeng

  • July 13, 2026

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