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1
Diabetes is linked to an increased risk of cognitive impairment and dementia, necessitating evaluation of antidiabetic medications' effects.
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2
A Bayesian network meta-analysis of 28 studies involving 4,382,897 patients assessed the relationship between antidiabetic drugs and dementia risk.
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3
Insulin, Metformin, and Pioglitazone significantly reduced dementia incidence compared to placebo, while DPP4i increased Alzheimer's and vascular dementia risk.
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4
Insulin showed the most significant efficacy in lowering dementia risk, while SGLT2i and GLP1 receptor agonists provided therapeutic benefits for Alzheimer's.
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5
The study aims to clarify the role of diabetes medications in cognitive health and inform clinical practices regarding dementia risk management.
