Evolving Perspectives in Psychosurgery: A Comprehensive Analysis from Lobotomy to Connectomics - Takeaways - MDSpire

Evolving Perspectives in Psychosurgery: A Comprehensive Analysis from Lobotomy to Connectomics

  • By

  • Victor González

  • Jordi Rumià

  • Marta Brell

  • Carolina Roset

  • José de Miguel

  • Susana Arboleya

  • Iratxe Aguirre

  • Daniel Alegre

  • Victor Goliney

  • Javier Ibáñez

  • April 23, 2026

  • 0 min

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  • 1

    Contemporary psychosurgery is evolving from invasive techniques to circuit-based medicine, focusing on targeted interventions within neural networks.

  • 2

    Modern psychosurgery employs techniques like focal ablation and reversible neuromodulation, moving away from broad, non-selective lesions.

  • 3

    Connectomics, including advanced imaging and graph-theoretical models, redefines treatment targets as nodes in fronto-limbic networks related to psychopathology.

  • 4

    Current psychosurgical methods include ablative approaches and stimulation-based interventions, each with specific mechanisms, advantages, and limitations.

  • 5

    The article advocates for precision psychiatry, emphasizing symptom dimensions and connectomic-guided targeting for treatment-resistant psychiatric disorders.

Original Source(s)

Evolving Perspectives in Psychosurgery: A Comprehensive Analysis from Lobotomy to Connectomics

  • by Victor González, Jordi Rumià, Marta Brell, Carolina Roset, José de Miguel, Susana Arboleya, Iratxe Aguirre, Daniel Alegre, Victor Goliney, Javier Ibáñez

  • April 23, 2026

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