Glucagon-stimulated copeptin response In Children: A Proof-Of-Concept Study - Takeaways - MDSpire

Glucagon-stimulated copeptin response In Children: A Proof-Of-Concept Study

  • By

  • Indirli, Rita

  • Giacchetti, Federico

  • Profka, Eriselda

  • Rodari, Giulia

  • Petria, Iulia

  • Arosio, Maura

  • Giavoli, Claudia

  • Mantovani, Giovanna

  • Ferrante, Emanuele

  • May 27, 2026

  • 0 min

Share

  • 1

    The study investigates copeptin response to glucagon stimulation in children suspected of growth hormone deficiency.

  • 2

    Twenty children participated, with a median age of 10.3 years and no history of polyuria-polydipsia syndrome.

  • 3

    Copeptin levels increased significantly from a baseline of 4.1 pmol/L to a peak of 10.6 pmol/L after glucagon injection.

  • 4

    The glucagon stimulation test was conducted safely, with no adverse events reported during the study.

  • 5

    The findings suggest that GST may enhance copeptin secretion in children, warranting further research on its diagnostic accuracy.

Original Source(s)

Glucagon-stimulated copeptin response In Children: A Proof-Of-Concept Study

  • by Indirli, Rita , Giacchetti, Federico , Profka, Eriselda , Rodari, Giulia , Petria, Iulia , Arosio, Maura , Giavoli, Claudia , Mantovani, Giovanna , Ferrante, Emanuele

  • May 27, 2026

Related Content

When Bad Data Enters the Drug Pipeline

Federal prosecutors allege that a Florida physician and research staff fabricated clinical trial records that were submitted into database systems used to evaluate investigational drugs.

Comparison of efficacy and safety between long-acting growth hormone and short-acting growth hormone in isolated growth hormone deficiency: a systematic review and meta-analysis of 16 randomized controlled trials involving 2,435 pediatric patients

Study Reassures on Safety of Early NSAID Use

A large cohort found no adjusted link to major congenital malformations, but questions remain for miscarriage, later pregnancy, and other outcomes.