Maternal obesity alters adipogenic potential and mitochondrial maximal respiration in infant mesenchymal stem cells - Takeaways - MDSpire

Maternal obesity alters adipogenic potential and mitochondrial maximal respiration in infant mesenchymal stem cells

  • By

  • Henry A. Paz

  • Ying Zhong

  • David K. Williams

  • Kartik Shankar

  • Aline Andres

  • Umesh D. Wankhade

  • April 2, 2026

  • 0 min

Share

  • 1

    Maternal obesity negatively impacts the adipogenic capacity of infant mesenchymal stem cells (UC-MSCs), reducing key adipogenic gene expression.

  • 2

    UC-MSCs from infants of overweight or obese mothers show diminished mitochondrial function compared to those from normal-weight mothers.

  • 3

    The study highlights a correlation between maternal BMI and altered expression of adipogenic markers Cebpa and Pparg in UC-MSCs.

  • 4

    Prenatal exposure to maternal obesity may predispose offspring to metabolic dysfunction and obesity due to disrupted adipose precursor programming.

  • 5

    The findings underscore the importance of maternal health during pregnancy in influencing long-term metabolic outcomes in children.

Original Source(s)

Maternal obesity alters adipogenic potential and mitochondrial maximal respiration in infant mesenchymal stem cells

  • by Henry A. Paz, Ying Zhong, David K. Williams, Kartik Shankar, Aline Andres, Umesh D. Wankhade

  • April 2, 2026

Related Content

Meta-inflammation in Hidradenitis suppurativa: from pathogenic evidence to therapeutic approaches

Grip Strength Plus Waist Size May Flag Risk T2D Risk

Researchers found that patients with higher waist circumference and lower grip strength had the greatest risk for developing type 2 diabetes during long-term follow-up.

GLP-1 Drugs Tied to Lower Addiction Risk

In a target-trial emulation of more than 600,000 veterans, GLP-1 RA initiators saw fewer new substance use disorders—and patients with existing SUDs had fewer overdoses, hospitalizations, and deaths.