Regional Adherence to Early Sepsis Management Bundle and Associated Mortality in Hong Kong Between 2009–2018 - Takeaways - MDSpire

Regional Adherence to Early Sepsis Management Bundle and Associated Mortality in Hong Kong Between 2009–2018

  • By

  • Jack Zhenhe Zhang

  • Chun Hei Chan

  • Lok Ching Chang

  • Lok Ching Sandra Chiu

  • Pauline Yeung Ng

  • Manimala Dharmangadan

  • Eunise Ho

  • Steven Ling

  • Man Yee Man

  • Ka Man Fong

  • Ting Liong

  • Alwin Wai Tak Yeung

  • Ka Fai Au

  • Jacky Ka Hing Chan

  • Michele Tang

  • Katy Hoi Ki Li

  • William Ka Kei Wu

  • Wai Tat Wong

  • Peng Wu

  • Benjamin J Cowling

  • Kwok Ming Ho

  • Anna Lee

  • Chanu Rhee

  • Lowell Ling

  • December 17, 2025

  • 0 min

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  • 1

    Full sepsis bundle adherence in Hong Kong increased from 0.2% in 2009 to 1.2% in 2018, indicating slow progress in compliance.

  • 2

    Empirical broad-spectrum antibiotic administration increased at a faster rate than antimicrobial resistance prevalence during the study period.

  • 3

    Full adherence to the sepsis management bundle was associated with a 25% reduction in hospital mortality rates.

  • 4

    Blood culture collection and appropriate use of broad-spectrum antibiotics were linked to lower mortality rates in sepsis patients.

  • 5

    Challenges in implementing basic sepsis care persist in high-income settings, highlighting the need for improved adherence and targeted treatments.

Original Source(s)

Regional Adherence to Early Sepsis Management Bundle and Associated Mortality in Hong Kong Between 2009–2018

  • by Jack Zhenhe Zhang, Chun Hei Chan, Lok Ching Chang, Lok Ching Sandra Chiu, Pauline Yeung Ng, Manimala Dharmangadan, Eunise Ho, Steven Ling, Man Yee Man, Ka Man Fong, Ting Liong, Alwin Wai Tak Yeung, Ka Fai Au, Jacky Ka Hing Chan, Michele Tang, Katy Hoi Ki Li, William Ka Kei Wu, Wai Tat Wong, Peng Wu, Benjamin J Cowling, Kwok Ming Ho, Anna Lee, Chanu Rhee, Lowell Ling

  • December 17, 2025

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