Is muscle strength an overlooked parameter in patients affected by mild autonomous cortisol secretion? - Takeaways - MDSpire

Is muscle strength an overlooked parameter in patients affected by mild autonomous cortisol secretion?

  • By

  • Martina Romanisio

  • Chiara Mele

  • Sara Sturnia

  • Carola Ciamparini

  • Rosa Pitino

  • Alice Ferrero

  • Lorenza Scotti

  • Madalina Elena Iftimie

  • Gianluca Aimaretti

  • Paolo Marzullo

  • Flavia Prodam

  • Marina Caputo

  • April 30, 2026

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  • 1

    Patients with mild autonomous cortisol secretion (MACS) exhibited a higher prevalence of osteopenia and osteoporosis compared to non-functioning adrenal adenomas (NFAA) and controls.

  • 2

    Muscle strength assessments revealed significantly reduced scores for biceps and quadriceps in MACS patients compared to healthy controls.

  • 3

    No significant differences in fat-free mass, muscle mass, or fat mass were observed among the groups studied.

  • 4

    Quality of life scores showed a trend toward greater impairment in patients with MACS, indicating potential functional deterioration.

  • 5

    The study highlights the under-recognized musculoskeletal impact of mild hypercortisolism, emphasizing the need for further investigation into muscle strength.

Original Source(s)

Is muscle strength an overlooked parameter in patients affected by mild autonomous cortisol secretion?

  • by Martina Romanisio, Chiara Mele, Sara Sturnia, Carola Ciamparini, Rosa Pitino, Alice Ferrero, Lorenza Scotti, Madalina Elena Iftimie, Gianluca Aimaretti, Paolo Marzullo, Flavia Prodam, Marina Caputo

  • April 30, 2026

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