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1
Acute kidney injury (AKI) is characterized by diverse etiologies and significant morbidity, contributing to over 1.5 million deaths annually.
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2
Dysregulated complement activation is a potential convergent mechanism of injury in various forms of AKI, though its contribution varies by etiology.
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3
Complement activation can be initiated by ischemia-reperfusion injury, nephrotoxins, and sepsis, leading to inflammatory escalation and tissue injury.
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4
The complement system plays a role in AKI by orchestrating endothelial activation, leukocyte recruitment, and tubular epithelial stress.
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5
Complement activation exhibits spatiotemporal heterogeneity, influenced by the renal compartment, injury stage, and persistence of activation.
