α-cell SLC38A5 supports amino acid-induced α-cell proliferation and glucagon secretion - Takeaways - MDSpire

α-cell SLC38A5 supports amino acid-induced α-cell proliferation and glucagon secretion

  • By

  • Katelyn Sellick

  • Anna Marie R. Schornack

  • Tyler J. Rodgers

  • Fedora O. Ogodo

  • Mounika Aramandla

  • Jade E. Stanley

  • Walter Siv

  • Matthew Shou

  • Nitin C. Shankar

  • Soham S. Saraf

  • Diana E. Stanescu

  • E. Danielle Dean

  • June 15, 2026

  • 0 min

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  • 1

    SLC38A5 is highly enriched in pancreatic α cells and plays a critical role in nutrient sensing and glucagon secretion.

  • 2

    α-cell-specific deletion of Slc38a5 significantly reduces amino acid-induced glucagon secretion and α-cell proliferation.

  • 3

    Phosphorylation of ribosomal protein S6 remains unaffected by SLC38A5 deletion, indicating SLC38A5-independent nutrient signaling.

  • 4

    The study utilized an α-cell-specific Slc38a5 knockout mouse model to investigate the direct effects of SLC38A5.

  • 5

    Findings highlight the importance of SLC38A5 in linking amino acid availability to α-cell growth and function.

Original Source(s)

α-cell SLC38A5 supports amino acid-induced α-cell proliferation and glucagon secretion

  • by Katelyn Sellick, Anna Marie R. Schornack, Tyler J. Rodgers, Fedora O. Ogodo, Mounika Aramandla, Jade E. Stanley, Walter Siv, Matthew Shou, Nitin C. Shankar, Soham S. Saraf, Diana E. Stanescu, E. Danielle Dean

  • June 15, 2026

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