GLP-1 Agents May Reduce Psoriasis Severity - Takeaways - MDSpire
From the Journals

GLP-1 Agents May Reduce Psoriasis Severity

National Psoriasis Foundation review highlights limited evidence and potential metabolic links

  • By

  • Andrea Surnit

  • May 5, 2026

  • 4 min

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  • 1

    GLP-1 RAs may reduce psoriasis severity in metabolic patients.

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    Significant PASI score reductions observed (40%-80%).

  • 3

    Semaglutide showed 52% PASI reduction in a trial with diabetic patients.

  • 4

    Evidence from studies is inconsistent, citing small sample sizes.

  • 5

    Potential adverse effects include gastrointestinal issues and rare skin conditions.

  • 6

    Not approved for psoriasis; use is off-label.

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    Can be coadministered with common psoriasis medications.

Original Source(s)

GLP-1 Agents May Reduce Psoriasis Severity

  • by Andrea Surnit

  • May 5, 2026

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