Melatonin-induced restoration of the intestinal mucosal barrier in inflammatory bowel disease via activation of the SIRT1-LKB1-pAMPK axis - Takeaways - MDSpire

Melatonin-induced restoration of the intestinal mucosal barrier in inflammatory bowel disease via activation of the SIRT1-LKB1-pAMPK axis

  • By

  • Qingyi Mao

  • Beibei Lin

  • Wenhao Xia

  • Yu Zhang

  • Yue Lei

  • Qian Cao

  • Mengque Xu

  • May 5, 2026

  • 0 min

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  • 1

    Melatonin levels are significantly lower in IBD patients, indicating a potential link between melatonin deficiency and intestinal health.

  • 2

    Melatonin supplementation enhances intestinal antimicrobial peptides and alleviates colitis in DSS-induced colitis mice.

  • 3

    The SIRT1-LKB1-pAMPK pathway is activated by melatonin, contributing to the restoration of the intestinal mucosal barrier.

  • 4

    Inhibition of SIRT1 or pAMPK abolishes the protective effects of melatonin, highlighting its mechanistic role in gut health.

  • 5

    Melatonin may improve IBD outcomes by regulating gut microbiota and reinforcing intestinal epithelial barrier integrity.

Original Source(s)

Melatonin-induced restoration of the intestinal mucosal barrier in inflammatory bowel disease via activation of the SIRT1-LKB1-pAMPK axis

  • by Qingyi Mao, Beibei Lin, Wenhao Xia, Yu Zhang, Yue Lei, Qian Cao, Mengque Xu

  • May 5, 2026

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