Discriminating prevalent type 2 diabetes among community-dwelling older adults with metabolic dysfunction-associated steatotic liver disease: a comparative analysis of 12 insulin resistance surrogates

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The study evaluated 12 surrogate insulin resistance indices for their association with prevalent type 2 diabetes in older adults with metabolic dysfunction-associated fatty liver disease.
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A total of 2641 participants were included, with 605 being older adults diagnosed with metabolic dysfunction-associated steatotic liver disease.
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TyG, TyG-ABSI, TyG-WWI, and TyG-WC were significantly associated with prevalent type 2 diabetes, with TyG showing the highest discriminatory ability.
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The area under the curve (AUC) for TyG was 0.726, indicating its effectiveness in identifying prevalent type 2 diabetes in the studied population.
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Sensitivity analyses confirmed the robustness of TyG as a metabolic marker for prevalent type 2 diabetes, even when excluding certain diagnostic criteria.

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