Heterogeneity in risk and potential pathogenic associations of NAFLD among distinct prediabetic phenotypes in young and middle-aged adults

1

Prediabetes significantly increases the risk of non-alcoholic fatty liver disease (NAFLD), with a prevalence of 38.32% among affected individuals.
2

Four distinct prediabetes phenotypes were identified, showing varying probabilities of NAFLD, with the highest prevalence in young individuals with severe insulin resistance.
3

Young individuals with moderate insulin resistance and overweight have a higher NAFLD risk linked to the metabolism-immunity-inflammation axis.
4

Middle-aged individuals with moderate insulin resistance and overweight primarily exhibit neutrophilic inflammation as a relevant factor for NAFLD.
5

The study's findings support targeted prevention strategies for NAFLD, moving away from a one-size-fits-all approach in managing prediabetes.

1