Lobectomy versus sublobar resection for stage I non-small cell lung cancer: an umbrella review of evidence quality, overlap, surgical-extent heterogeneity, and survival outcomes - Takeaways - MDSpire

Lobectomy versus sublobar resection for stage I non-small cell lung cancer: an umbrella review of evidence quality, overlap, surgical-extent heterogeneity, and survival outcomes

  • By

  • Xiang Lin

  • Jingwen Zhang

  • Beinuo Wang

  • Zhenghao Dong

  • Yu Tong

  • Jian Zhou

  • Hu Liao

  • June 5, 2026

  • 0 min

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  • 1

    This umbrella review evaluates the comparative efficacy of lobectomy versus sublobar resection for Stage I non-small cell lung cancer (NSCLC).

  • 2

    Eighteen systematic reviews were included, with varying methodological quality, highlighting the need for comprehensive evidence assessment.

  • 3

    Sublobar resection showed a statistically significant higher hazard for overall survival and disease-free survival in the broader Stage I population.

  • 4

    Substantial heterogeneity and low certainty of evidence limited the reliability of overall survival estimates in the analyses.

  • 5

    The review emphasizes the importance of individualized clinical decision-making based on the quality and applicability of existing evidence.

Original Source(s)

Lobectomy versus sublobar resection for stage I non-small cell lung cancer: an umbrella review of evidence quality, overlap, surgical-extent heterogeneity, and survival outcomes

  • by Xiang Lin, Jingwen Zhang, Beinuo Wang, Zhenghao Dong, Yu Tong, Jian Zhou, Hu Liao

  • June 5, 2026

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