Neutrophil-derived ROS as a rapid functional biomarker: diagnostic and prognostic performance of the Leukocyte ImmunoTest in infection and sepsis - Takeaways - MDSpire

Neutrophil-derived ROS as a rapid functional biomarker: diagnostic and prognostic performance of the Leukocyte ImmunoTest in infection and sepsis

  • By

  • Nazlıhan Boyacı Dündar

  • David Sarphie

  • Kenan Yüce

  • Gülbin Aygencel

  • Melda Türkoğlu

  • Rubina Mian

  • Paul Moss

  • Mustafa Necmi İlhan

  • Gülendam Bozdayı

  • June 29, 2026

  • 0 min

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  • 1

    The Leukocyte ImmunoTest (LIT) quantifies neutrophil-derived reactive oxygen species (ROS) to provide rapid insights into immune dysregulation in infection and sepsis.

  • 2

    In a study, median LIT values significantly increased across diagnostic groups: controls (470 RLU), infection (882 RLU), and sepsis (2466 RLU).

  • 3

    LIT demonstrated strong diagnostic performance for identifying infection (AUC: 0.94) and sepsis (AUC: 0.86), comparable to established biomarkers like CRP and PCT.

  • 4

    Higher LIT values were independently associated with increased mortality, indicating its potential prognostic value in sepsis management.

  • 5

    The study suggests that LIT may serve as a complementary biomarker in sepsis, warranting further multicenter studies for validation.

Original Source(s)

Neutrophil-derived ROS as a rapid functional biomarker: diagnostic and prognostic performance of the Leukocyte ImmunoTest in infection and sepsis

  • by Nazlıhan Boyacı Dündar, David Sarphie, Kenan Yüce, Gülbin Aygencel, Melda Türkoğlu, Rubina Mian, Paul Moss, Mustafa Necmi İlhan, Gülendam Bozdayı

  • June 29, 2026

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