Assessing the Effectiveness of Tonsillectomy for PFAPA Syndrome: A Systematic Review and Meta-Analysis

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The systematic review evaluated the effectiveness of tonsillectomy for treating PFAPA syndrome through a meta-analysis of randomized controlled trials.
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Three randomized controlled trials involving 81 patients met the inclusion criteria, showing significant improvement in postoperative complete remission rates.
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Tonsillectomy significantly reduced the frequency of fever episodes, with a mean difference of -0.41 episodes per person-month.
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The pooled mean difference in fever duration was -3.15 days, but this result was not statistically significant and showed substantial heterogeneity.
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No postoperative complications were reported, but the authors noted the need for larger, well-designed RCTs to confirm these findings.

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