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1
Immunotherapy has led to new ICU-relevant complications in cancer patients, including hyperinflammatory syndromes and organ-specific immune injuries.
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2
Key complications associated with immunotherapy include cytokine release syndrome, neurotoxicity, severe pneumonitis, and myocarditis.
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3
The clinical presentation of immunotherapy-related toxicities often overlaps with sepsis and other ICU syndromes, complicating diagnosis.
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4
A significant proportion of immunotherapy-related emergencies are potentially reversible, challenging traditional views on ICU admissions for cancer.
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5
Optimal management of immunotherapy-related critical illness requires early ICU escalation, integrated supportive care, and syndrome-directed treatment.
