Efficacy and safety of different antithrombotic treatment regimens in patients undergoing transcatheter mitral valve repair and atrial fibrillation; A meta-analysis and systematic review - Takeaways - MDSpire

Effectiveness and safety of various antithrombotic strategies in patients with atrial fibrillation undergoing transcatheter mitral valve repair: A systematic review and network meta-analysis

  • By

  • Fuli Zhu

  • Zihan Yu

  • Zhe He

  • July 21, 2026

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  • 1

    A systematic review and network meta-analysis evaluated antithrombotic strategies in patients with atrial fibrillation undergoing TMVR.

  • 2

    Oral anticoagulation (OAC) strategies showed a favorable profile for bleeding risk reduction compared to antiplatelet therapy (APT).

  • 3

    Direct oral anticoagulants (DOACs) exhibited heterogeneous results based on the comparator drug and study region.

  • 4

    OAC strategies were associated with lower bleeding risk and potentially favorable mortality outcomes compared to APT.

  • 5

    The evidence base is limited by observational design, heterogeneous comparators, and inconsistent outcome definitions.

Original Source(s)

Efficacy and safety of different antithrombotic treatment regimens in patients undergoing transcatheter mitral valve repair and atrial fibrillation; A meta-analysis and systematic review

  • by Fuli Zhu, Zihan Yu, Zhe He

  • July 21, 2026

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