Progesterone Linked to Brain Structure Changes

MRI study finds stronger associations than estradiol across menstrual phases

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Progesterone shows stronger associations with brain structure changes than estradiol, according to a study in eBioMedicine.
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Total gray matter volume was significantly higher during the periovulatory phase compared to menstruation in healthy women.
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Higher progesterone levels during the periovulatory phase correlated with increased volume in cerebellar regions.
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Cortical thickness exhibited phase-dependent associations across various brain regions, influenced by hormone levels.
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Findings suggest progesterone may drive hormone-related structural brain changes, with effects varying by menstrual phase.