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Progesterone Linked to Brain Structure Changes

MRI study finds stronger associations than estradiol across menstrual phases

  • By

  • Meg Barbor

  • March 30, 2026

  • 2 min

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  • 1

    Progesterone shows stronger associations with brain structure changes than estradiol, according to a study in eBioMedicine.

  • 2

    Total gray matter volume was significantly higher during the periovulatory phase compared to menstruation in healthy women.

  • 3

    Higher progesterone levels during the periovulatory phase correlated with increased volume in cerebellar regions.

  • 4

    Cortical thickness exhibited phase-dependent associations across various brain regions, influenced by hormone levels.

  • 5

    Findings suggest progesterone may drive hormone-related structural brain changes, with effects varying by menstrual phase.

Original Source(s)

Progesterone Linked to Brain Structure Changes

  • by Meg Barbor

  • March 30, 2026

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