Characterization of the tumor microenvironment in locally advanced gastric cancer and identification of spatially predictive biomarkers associated with beneficial neoadjuvant immunochemotherapy - Takeaways - MDSpire

Characterization of the tumor microenvironment in locally advanced gastric cancer and identification of spatially predictive biomarkers associated with beneficial neoadjuvant immunochemotherapy

  • By

  • Xiaohong Xu

  • Jun Fan

  • Li Peng

  • Zhengkai Xiang

  • Danju Luo

  • Chenggong Ma

  • Bo Huang

  • Xiu Nie

  • Xiaochuan Dong

  • May 14, 2026

  • 0 min

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  • 1

    Neoadjuvant immunochemotherapy (nICT) shows promise for locally advanced gastric cancer (LAGC), but reliable predictive biomarkers are lacking.

  • 2

    Digital spatial profiling (DSP) was used to analyze tumor microenvironment (TME) in 19 LAGC patients treated with tislelizumab and SOX chemotherapy.

  • 3

    Key biomarkers identified include NOTUM, SERPINA3, and CD8+ T cell density, which correlate with major pathological response (MPR) to nICT.

  • 4

    A six-gene signature associated with survival and immune infiltration was identified, highlighting conserved immune-modulatory patterns across cancers.

  • 5

    The study emphasizes the importance of spatial TME analysis in discovering biomarkers that can guide personalized immunotherapeutic strategies.

Original Source(s)

Characterization of the tumor microenvironment in locally advanced gastric cancer and identification of spatially predictive biomarkers associated with beneficial neoadjuvant immunochemotherapy

  • by Xiaohong Xu, Jun Fan, Li Peng, Zhengkai Xiang, Danju Luo, Chenggong Ma, Bo Huang, Xiu Nie, Xiaochuan Dong

  • May 14, 2026

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