In Vivo Gastric Expression of FTO and MC4R in Sleeve Gastrectomy Patients: Diagnostic Utility Without Predictive Value for Weight Loss - Takeaways - MDSpire

In Vivo Gastric Expression of FTO and MC4R in Sleeve Gastrectomy Patients: Diagnostic Utility Without Predictive Value for Weight Loss

  • By

  • Mohamed Hany

  • Mona K. ElDeeb

  • Ehab Elmongui

  • Anwar Ashraf Abouelnasr

  • Noha A. El-Banna

  • Sahar M. omer

  • Sara A. Shaker

  • Rasha A. ElTahan

  • December 9, 2025

  • 0 min

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  • 1

    Obesity is a chronic disease characterized by energy dysregulation, significantly increasing the risk of type 2 diabetes and cardiovascular diseases.

  • 2

    The FTO gene is a major polygenic contributor to obesity, influencing energy intake and body mass index through various genetic polymorphisms.

  • 3

    The MC4R gene regulates energy homeostasis and appetite, with its expression documented in multiple tissues, including the gastrointestinal tract.

  • 4

    Gastric gene expression of FTO and MC4R may impact local gastric functions and metabolic processes, but lacks direct correlation with overall body fat.

  • 5

    Current research indicates that genetic variants in FTO and MC4R act as expression quantitative trait loci, influencing obesity-related gene expression.

Original Source(s)

In Vivo Gastric Expression of FTO and MC4R in Sleeve Gastrectomy Patients: Diagnostic Utility Without Predictive Value for Weight Loss

  • by Mohamed Hany, Mona K. ElDeeb, Ehab Elmongui, Anwar Ashraf Abouelnasr, Noha A. El-Banna, Sahar M. omer, Sara A. Shaker, Rasha A. ElTahan

  • December 9, 2025

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