N-Myc and STAT interactor as a context-dependent switch in innate antiviral immunity - Takeaways - MDSpire

N-Myc and STAT interactor as a context-dependent switch in innate antiviral immunity

  • By

  • Lin Han

  • Xinyao Xu

  • Fangfang Zhao

  • Luyu Mao

  • Yongli Guo

  • Mingchun Gao

  • June 24, 2026

  • 0 min

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  • 1

    N-Myc and STAT interactor (NMI) is a regulatory node in innate antiviral immunity, influenced by interacting partners and signaling context.

  • 2

    NMI suppresses IRF7-dependent type I interferon signaling in acute RNA virus models, facilitating viral replication.

  • 3

    In foamy virus infection, NMI acts as a host restriction factor by binding the viral transactivator Tas and suppressing viral transcription.

  • 4

    During human cytomegalovirus infection, NMI is targeted by the viral protein UL23, which interferes with the NMI–STAT1/IFN-γ axis.

  • 5

    Extracellular NMI and IFP35 can amplify inflammation as damage-associated molecular patterns, linking immune responses to tissue stress.

Original Source(s)

N-Myc and STAT interactor as a context-dependent switch in innate antiviral immunity

  • by Lin Han, Xinyao Xu, Fangfang Zhao, Luyu Mao, Yongli Guo, Mingchun Gao

  • June 24, 2026

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