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1
Chronic Post-Surgical Pain (CPSP) is defined as pain lasting for ≥3 months post-surgery, localized to the surgical area, with other causes excluded.
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2
Postoperative Chronic Opioid Use (COU) is characterized by prolonged opioid utilization, defined as ≥10 prescriptions or ≥120 days’ supply in the postsurgical year.
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3
Preoperative psychosocial factors, such as anxiety and catastrophizing, are significant predictors of CPSP and COU, necessitating thorough risk stratification.
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4
Anesthesiologists can mitigate CPSP and COU through targeted interventions, including regional anesthesia and non-opioid adjuncts like intravenous lidocaine.
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5
A precision medicine approach is essential for addressing individual variability in CPSP and COU, focusing on mechanism-based perioperative analgesia.
