The role of macrophage polarization in organ transplantation: research progress on impact on graft injury, repair, and fibrosis - Takeaways - MDSpire

Macrophage Polarization in Organ Transplantation: Advances in Understanding Its Effects on Graft Injury, Repair, and Fibrosis

  • By

  • Liping Wang

  • Lijuan Wang

  • Xu Chen

  • Shaochen Yu

  • July 17, 2026

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  • 1

    Macrophages play a crucial role in organ transplantation, influencing graft injury, immune rejection, and chronic fibrosis.

  • 2

    Macrophages can polarize into pro-inflammatory M1 or anti-inflammatory M2 phenotypes, affecting transplant outcomes.

  • 3

    Ischemia-reperfusion injury activates macrophages, leading to distinct responses from tissue-resident and monocyte-derived macrophages.

  • 4

    The regulatory network of macrophage polarization involves complex signaling pathways, including the JAK-STAT pathway.

  • 5

    Therapeutic strategies targeting macrophage polarization may improve long-term graft survival and function.

Original Source(s)

The role of macrophage polarization in organ transplantation: research progress on impact on graft injury, repair, and fibrosis

  • by Liping Wang, Lijuan Wang, Xu Chen, Shaochen Yu

  • July 17, 2026

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