Case Report: Complete endoscopic submucosal dissection for occult superficial esophageal squamous cell carcinoma concealed by a large esophageal leiomyoma - Takeaways - MDSpire

Case Report: Complete endoscopic submucosal dissection for occult superficial esophageal squamous cell carcinoma concealed by a large esophageal leiomyoma

  • By

  • Xiaoying Yang

  • Yaowen Hu

  • Wangyang Chen

  • Shengyu Zhang

  • Yonglin Wang

  • Kun He

  • Qingwei Jiang

  • Dong Wu

  • May 20, 2026

  • 0 min

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  • 1

    A 53-year-old woman with a large esophageal leiomyoma was found to have superficial esophageal squamous cell carcinoma (ESCC) during routine endoscopy.

  • 2

    Subtle mucosal irregularity detected on endoscopy led to further evaluation, confirming carcinoma in situ through targeted biopsies.

  • 3

    Selective endoscopic submucosal dissection (ESD) was performed, achieving complete resection of the carcinoma while preserving the leiomyoma.

  • 4

    Histopathology confirmed well-differentiated superficial ESCC with negative margins, but additional surgery was recommended due to submucosal invasion.

  • 5

    At 2-year follow-up, there was no recurrence of ESCC, and the leiomyoma remained stable, highlighting the importance of careful evaluation for hidden malignancies.

Original Source(s)

Case Report: Complete endoscopic submucosal dissection for occult superficial esophageal squamous cell carcinoma concealed by a large esophageal leiomyoma

  • by Xiaoying Yang, Yaowen Hu, Wangyang Chen, Shengyu Zhang, Yonglin Wang, Kun He, Qingwei Jiang, Dong Wu

  • May 20, 2026

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