Case Report: Allergic reaction following fecal microbiota transplantation in children with autism spectrum disorder: a report of two cases - Takeaways - MDSpire

Case Report: Allergic reaction following fecal microbiota transplantation in children with autism spectrum disorder: a report of two cases

  • By

  • Zhihui Peng

  • Yuanbing Hu

  • Sheng Wang

  • Chunhua Liu

  • Qi Zhou

  • Shiyu Xie

  • Silin Huang

  • Nan Liu

  • Yanli Wang

  • June 16, 2026

  • 0 min

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  • 1

    Fecal microbiota transplantation (FMT) is increasingly used in children with autism spectrum disorder (ASD) but carries risks of severe adverse events.

  • 2

    Two cases of children with ASD and multiple food intolerances developed anaphylactic shock following FMT, marking the first report of such events in pediatrics.

  • 3

    Case 1 experienced early-stage shock linked to IgG-mediated hypersensitivity, while Case 2 had classic anaphylactic shock with a biphasic course.

  • 4

    Both children improved after anti-allergy and anti-shock treatment, with one successfully completing subsequent FMT using a low-dose regimen.

  • 5

    The report emphasizes the need for refined risk stratification and monitoring during FMT in high-risk pediatric patients with ASD and food intolerances.

Original Source(s)

Case Report: Allergic reaction following fecal microbiota transplantation in children with autism spectrum disorder: a report of two cases

  • by Zhihui Peng, Yuanbing Hu, Sheng Wang, Chunhua Liu, Qi Zhou, Shiyu Xie, Silin Huang, Nan Liu, Yanli Wang

  • June 16, 2026

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