Predictors of false−negative serum thyroglobulin in persistent/recurrent Papillary Thyroid Carcinoma cervical lymph nodes - Takeaways - MDSpire

Predictors of false−negative serum thyroglobulin in persistent/recurrent Papillary Thyroid Carcinoma cervical lymph nodes

  • By

  • Jing Lin

  • Alibiyati Aini

  • Zien Qin

  • June 17, 2026

  • 0 min

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  • 1

    Serum thyroglobulin (Tg) is the primary biomarker for monitoring disease persistence and recurrence in papillary thyroid carcinoma (PTC).

  • 2

    In a study of 215 PTC patients, 22.3% had unstimulated serum Tg levels below 0.2 ng/mL despite confirmed persistent/recurrent cervical lymph nodes.

  • 3

    Independent predictors of false-negative Tg included central lymph node location, smaller lymph node size, and higher Tg-antibody levels.

  • 4

    A nomogram developed in the study showed good discrimination for identifying high-risk individuals with false-negative Tg results.

  • 5

    The study highlights the need for adjunct imaging and biopsy in patients with high-risk factors where serum Tg alone is unreliable.

Original Source(s)

Predictors of false−negative serum thyroglobulin in persistent/recurrent Papillary Thyroid Carcinoma cervical lymph nodes

  • by Jing Lin, Alibiyati Aini, Zien Qin

  • June 17, 2026

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