Orchestration of the tumor microenvironment by citrus flavonoids: from preclinical mechanisms to translational therapeutic - Takeaways - MDSpire

Orchestration of the tumor microenvironment by citrus flavonoids: from preclinical mechanisms to translational therapeutic

  • By

  • Siyao Ma

  • Xuebing Wang

  • Mingzhu Li

  • Wenping Wang

  • Yanyi Ren

  • Yue Shen

  • Ke Yang

  • Ze Zhang

  • Zitong Feng

  • Shuhan Tang

  • May 4, 2026

  • 0 min

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  • 1

    Citrus flavonoids from Citri Reticulatae Pericarpium modulate the lung cancer tumor microenvironment, aiding in overcoming therapy resistance.

  • 2

    Key mechanisms of CRP flavonoids include regulating oxidative stress, lipid metabolism, inducing pyroptosis, and inhibiting epithelial-mesenchymal transition.

  • 3

    Emerging targets like ferroptosis and the cGAS-STING pathway represent significant gaps in current research on CRP flavonoids in lung cancer.

  • 4

    CRP flavonoids have favorable toxicity profiles and potent immunomodulatory properties, making them promising candidates for lung cancer treatment.

  • 5

    The review identifies barriers to clinical translation of CRP flavonoids and highlights the need for further research on multi-target mechanisms.

Original Source(s)

Orchestration of the tumor microenvironment by citrus flavonoids: from preclinical mechanisms to translational therapeutic

  • by Siyao Ma, Xuebing Wang, Mingzhu Li, Wenping Wang, Yanyi Ren, Yue Shen, Ke Yang, Ze Zhang, Zitong Feng, Shuhan Tang

  • May 4, 2026

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