Synovial Fluid Cell Profiling Identifies Distinct Inflammatory Phenotypes in Late-Onset Rheumatoid Arthritis and Polymyalgia Rheumatica - Takeaways - MDSpire

Cellular Analysis of Synovial Fluid Reveals Unique Inflammatory Profiles in Late-Onset Rheumatoid Arthritis and Polymyalgia Rheumatica

  • By

  • Shigeru Tanaka

  • Takahiro Sugiyama

  • Shuhei Kameda

  • Tatsuro Takahashi

  • Masahiro Yasui

  • Yuki Hayashi

  • Tomoaki Ida

  • Yuhi Yoshida

  • Soichiro Kubota

  • Takashi Ito

  • Takahiro Kageyama

  • Daiki Nakagomi

  • Kei Ikeda

  • Shin-Ichiro Kagami

  • Hiroshi Nakajima

  • July 1, 2026

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  • 1

    Late-onset rheumatoid arthritis (LORA) occurs in individuals aged 60 years or older and presents distinct characteristics compared to young-onset RA.

  • 2

    Polymyalgia rheumatica (PMR) is an inflammatory condition affecting individuals over 50, often complicating the differentiation from ACPA-negative LORA.

  • 3

    Synovial fluid analysis may provide more relevant insights into inflammatory profiles compared to systemic biomarkers in elderly patients.

  • 4

    The study included 21 East Asian patients, categorized into ACPA-positive LORA, ACPA-negative LORA, and PMR, with most being newly diagnosed.

  • 5

    High-dimensional cytometry by time-of-flight (CyTOF) was employed to analyze synovial fluid immune cells and their activation states.

Original Source(s)

Synovial Fluid Cell Profiling Identifies Distinct Inflammatory Phenotypes in Late-Onset Rheumatoid Arthritis and Polymyalgia Rheumatica

  • by Shigeru Tanaka, Takahiro Sugiyama, Shuhei Kameda, Tatsuro Takahashi, Masahiro Yasui, Yuki Hayashi, Tomoaki Ida, Yuhi Yoshida, Soichiro Kubota, Takashi Ito, Takahiro Kageyama, Daiki Nakagomi, Kei Ikeda, Shin-Ichiro Kagami, Hiroshi Nakajima

  • July 1, 2026

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