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1
Anti-metabotropic glutamate receptor 1 (mGluR1) encephalitis is a rare autoimmune encephalitis variant often linked to cerebellar dysfunction.
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2
An 87-year-old male presented with subacute symptoms including fever, dysarthria, limb weakness, and altered mental status.
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3
Diagnostic tests confirmed anti-mGluR1 antibodies in serum and cerebrospinal fluid, while next-generation sequencing showed no infectious agents.
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4
Brain MRI revealed extensive hyperintensity affecting the midbrain, pons, and medulla, indicating significant brainstem involvement.
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5
Testing for anti-mGluR1 antibodies may be warranted in cases of unexplained subacute inflammatory brainstem syndromes.
