MRI-derived body fat distribution patterns are linked to gray matter atrophy and cognitive decline in a UK Biobank study of nearly 26,000 patients.
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Six fat distribution profiles were identified, including pancreatic-predominant and skinny-fat, with distinct impacts on brain health.
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The pancreatic-predominant profile exhibited significant gray matter atrophy, particularly in anterior brain regions for both sexes.
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Lower cognitive performance, including psychomotor speed and memory, was observed in patients with certain fat distribution profiles compared to lean individuals.
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The study emphasizes the importance of considering fat distribution patterns over body mass index when evaluating neurologic disease risks.
