Severe-extensive coronary atherosclerosis in low-risk individuals and absence of coronary atherosclerosis in high-risk individuals: the SCAPIS extremes project - Takeaways - MDSpire

Severe-extensive coronary atherosclerosis in low-risk individuals and absence of coronary atherosclerosis in high-risk individuals: the SCAPIS extremes project

  • By

  • Madeleine Johansson

  • Göran Bergström

  • Tomas Jernberg

  • Emil Hagström

  • Stefan Söderberg

  • Carl Johan Östgren

  • Gunnar Engström

  • Anders Gottsäter

  • Peter M Nilsson

  • July 11, 2025

  • 0 min

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  • 1

    The SCAPIS Extremes Study analyzed coronary atherosclerosis in 30,154 individuals aged 50-64, revealing unexpected patterns in high and low CV risk groups.

  • 2

    1.2% of non-diabetic and 14.0% of diabetic subjects exhibited no coronary plaques despite high cardiovascular risk, highlighting a significant mismatch.

  • 3

    Severe coronary plaque burden was found in 0.7% of non-diabetic and 0.3% of diabetic subjects despite low cardiovascular risk, indicating extreme phenotypes.

  • 4

    Factors linked to severe atherosclerosis in low-risk individuals included male gender, older age, smoking history, hypertension, and family history of CVD.

  • 5

    The study emphasizes the need for improved cardiovascular risk assessment tools to better identify individuals at risk for coronary atherosclerosis.

Original Source(s)

Severe-extensive coronary atherosclerosis in low-risk individuals and absence of coronary atherosclerosis in high-risk individuals: the SCAPIS extremes project

  • by Madeleine Johansson, Göran Bergström, Tomas Jernberg, Emil Hagström, Stefan Söderberg, Carl Johan Östgren, Gunnar Engström, Anders Gottsäter, Peter M Nilsson

  • July 11, 2025

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