An advanced, highly sensitive and versatile Cypridina luciferase-based HPV pseudovirus system for broad-spectrum neutralization and non-invasive In vivo monitoring - Takeaways - MDSpire

An advanced, highly sensitive and versatile Cypridina luciferase-based HPV pseudovirus system for broad-spectrum neutralization and non-invasive In vivo monitoring

  • By

  • Hyemi Kim

  • Chai Won Kim

  • Kihyuck Kwak

  • May 29, 2026

  • 0 min

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  • 1

    A novel pseudovirus platform using Cypridina luciferase (cLuc) enhances HPV neutralization assays by eliminating serum heat inactivation.

  • 2

    The cLuc-engineered pseudoviruses cover 28 HPV genotypes and maintain excellent correlation with traditional SEAP assays.

  • 3

    This system allows for non-invasive tracking of mucosal infections in vivo using real-time bioluminescence imaging.

  • 4

    The cLuc-PsV platform provides a sensitive and efficient alternative to conventional neutralization assays.

  • 5

    The dual-purpose nature of cLuc enables both high-throughput in vitro quantification and longitudinal in vivo imaging.

Original Source(s)

An advanced, highly sensitive and versatile Cypridina luciferase-based HPV pseudovirus system for broad-spectrum neutralization and non-invasive In vivo monitoring

  • by Hyemi Kim, Chai Won Kim, Kihyuck Kwak

  • May 29, 2026

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