Endothelial cell damage in patients with acute graft versus host disease receiving treatment with extracorporeal photopheresis

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Extracorporeal photopheresis (ECP) is an effective treatment for steroid-refractory acute graft-versus-host disease (SR-aGVHD).
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Endothelial damage biomarkers were measured in plasma from 35 SR-aGVHD patients before and after one month of ECP treatment.
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A panel of five biomarkers could identify good responders to ECP after one month, aiding in predicting treatment response.
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Elevated endothelial damage biomarkers were found in all patients prior to ECP, with no significant differences between good and poor responders.
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Increased REG3alpha and sC5b9 levels, along with decreased TIM3 levels, were observed in poor responders after one month of ECP.

Frontiers In Immunology

by Julia Martinez-Sanchez, Paola Charry, Ana Belén Moreno-Castaño, Alex Ramos, Sergi Torramade-Moix, Helena Ventosa-Capell, Marta Palomo, Olaf Penack, María Queralt Salas, María Suárez-Lledó, Francesc Fernández-Avilés, Carmen Martínez, Laura Rosiñol, Montserrat Rovira, Enric Carreras, Miquel Lozano, Gines Escolar, Joan Cid, Maribel Diaz-Ricart
June 15, 2026

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