Hypoxia-inducible factor 1-alpha: a dual regulator of ferroptosis in ischemic stroke and a promising therapeutic target - Takeaways - MDSpire

Hypoxia-inducible factor 1-alpha: a dual regulator of ferroptosis in ischemic stroke and a promising therapeutic target

  • By

  • Qian Cui

  • Can Guo

  • Yinxiang Luo

  • Dingding Liu

  • Dong Wang

  • Zhe Wang

  • Zhiguang Xu

  • June 30, 2026

  • 0 min

Share

  • 1

    Ischemic stroke (IS) is a leading cause of disability and mortality, accounting for 60-70% of all stroke cases globally.

  • 2

    Ferroptosis is a newly identified form of non-apoptotic cell death that significantly contributes to the progression of IS.

  • 3

    Hypoxia-inducible factor 1-alpha (HIF-1α) plays a dual role in IS, exerting both neuroprotective and neurotoxic effects.

  • 4

    HIF-1α regulates ferroptosis through mechanisms involving iron metabolism, lipid peroxidation, and oxidative stress.

  • 5

    Therapeutic approaches targeting HIF-1α to modulate ferroptosis include prolyl hydroxylase inhibitors and deferoxamine.

Original Source(s)

Hypoxia-inducible factor 1-alpha: a dual regulator of ferroptosis in ischemic stroke and a promising therapeutic target

  • by Qian Cui, Can Guo, Yinxiang Luo, Dingding Liu, Dong Wang, Zhe Wang, Zhiguang Xu

  • June 30, 2026

Related Content

Effects of transcutaneous auricular vagus nerve stimulation on patients with post-stroke insomnia: a randomized controlled trial protocol

Brain cell-released Cyclophilin A induces neuroinflammation and exacerbates blood–brain barrier injury in acute ischemic stroke

Case Report: Recurrent cerebral embolism secondary to direct cardiac invasion by lung adenocarcinoma