Distinct Serum Extracellular Vesicle Proteomic Profiles Characterize Hepatic Steatosis in Women After Menopause - Takeaways - MDSpire

Distinct Serum Extracellular Vesicle Proteomic Profiles Characterize Hepatic Steatosis in Women After Menopause

  • By

  • Patrick Pirrotte

  • Brooke Lovell

  • Siobán D. Harlow

  • Carrie A. Karvonen-Gutierrez

  • Michelle M. Hood

  • Ignazio S. Piras

  • Xiumei Wu

  • Melissa N. Martinez

  • Ritin Sharma

  • Krystine Garcia-Mansfield

  • Maya Willey

  • Johanna K. DiStefano

  • December 7, 2025

  • 0 min

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  • 1

    Postmenopausal women experience significant metabolic changes, increasing their risk for metabolic dysfunction-associated steatotic liver disease (MASLD).

  • 2

    The prevalence of MASLD in women has risen sharply, with postmenopausal women showing a higher likelihood of advanced fibrosis compared to men.

  • 3

    Extracellular vesicles (EVs) are emerging as potential biomarkers for early detection of MASLD, carrying diverse biomolecules reflective of cellular states.

  • 4

    Current clinical assessments for liver health have limitations in detecting early stages of MASLD, highlighting the need for improved diagnostic strategies.

  • 5

    The study utilizes serum samples from the SWAN cohort to explore EV-derived proteomic profiles linked to hepatic steatosis in postmenopausal women.

Original Source(s)

Distinct Serum Extracellular Vesicle Proteomic Profiles Characterize Hepatic Steatosis in Women After Menopause

  • by Patrick Pirrotte, Brooke Lovell, Siobán D. Harlow, Carrie A. Karvonen-Gutierrez, Michelle M. Hood, Ignazio S. Piras, Xiumei Wu, Melissa N. Martinez, Ritin Sharma, Krystine Garcia-Mansfield, Maya Willey, Johanna K. DiStefano

  • December 7, 2025

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