Management of Post-Traumatic Aggression in a Child with Traumatic Brain Injury: A Case Study on Long-Acting Injectable Paliperidone and a Review of Relevant Literature - Takeaways - MDSpire

Management of Post-Traumatic Aggression in a Child with Traumatic Brain Injury: A Case Study on Long-Acting Injectable Paliperidone and a Review of Relevant Literature

  • By

  • Abdullah Al Ghailani

  • Samir Al Adawi

  • Hassan Mirza

  • April 29, 2026

  • 0 min

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  • 1

    Post-traumatic confusional state (PTCS) can severely affect children with traumatic brain injury (TBI), leading to aggression and poor impulse control.

  • 2

    A 9-year-old boy with severe TBI showed significant improvement in aggression and functional status after treatment with long-acting injectable paliperidone.

  • 3

    Previous oral medications for the child, including risperidone and olanzapine, provided minimal benefit and faced adherence issues.

  • 4

    Cognitive testing at age 19 revealed average intellectual ability but persistent executive dysfunction following treatment.

  • 5

    Further research is needed to evaluate the efficacy and safety of long-acting antipsychotics like paliperidone in pediatric TBI patients.

Original Source(s)

Management of Post-Traumatic Aggression in a Child with Traumatic Brain Injury: A Case Study on Long-Acting Injectable Paliperidone and a Review of Relevant Literature

  • by Abdullah Al Ghailani, Samir Al Adawi, Hassan Mirza

  • April 29, 2026

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