Polymorphism analysis of estrogen receptor β Gene RsaI and AluI in girls with idiopathic central precocious puberty: investigating the relationship and implications for early risk prediction - Takeaways - MDSpire

Polymorphism analysis of estrogen receptor β Gene RsaI and AluI in girls with idiopathic central precocious puberty: investigating the relationship and implications for early risk prediction

  • By

  • Peipei Liu

  • Guoqing Dong

  • Mingzhu Li

  • Miao Huang

  • Xiyan Lu

  • Jianxu Li

  • June 17, 2026

  • 0 min

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  • 1

    The study investigates the association between ERβ gene RsaI and AluI polymorphisms and idiopathic central precocious puberty (ICPP) in girls.

  • 2

    Significant differences in ERβ RsaI polymorphism were found between ICPP girls and controls, with the R allele linked to increased ICPP risk.

  • 3

    No significant association was observed for the AluI polymorphism in terms of genotype distribution or allele frequency between the groups.

  • 4

    Haplotype analysis revealed a significant difference in haplotype distribution, with the Rraa haplotype more frequent in the ICPP group.

  • 5

    The findings suggest that ERβ RsaI genotyping could aid in early risk assessment for ICPP, warranting further multicenter studies for validation.

Original Source(s)

Polymorphism analysis of estrogen receptor β Gene RsaI and AluI in girls with idiopathic central precocious puberty: investigating the relationship and implications for early risk prediction

  • by Peipei Liu, Guoqing Dong, Mingzhu Li, Miao Huang, Xiyan Lu, Jianxu Li

  • June 17, 2026

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