Is hidradenitis suppurativa more an autoinfection than pure autoinflammation? - Takeaways - MDSpire

Is hidradenitis suppurativa more an autoinfection than pure autoinflammation?

  • By

  • Maïa Delage

  • Olivier Join-Lambert

  • Snaigune Miskinyte

  • Alain Hovnanian

  • Aude Nassif

  • July 6, 2026

  • 0 min

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  • 1

    Hidradenitis suppurativa (HS) is currently classified as an autoinflammatory disease, but its inflammation source remains unknown.

  • 2

    A cohort of 1,700 HS patients over 18 years suggests HS may represent a host-microbiome disease rather than solely autoinflammatory.

  • 3

    Microbiological findings indicate abnormal bacteria presence in HS lesions, correlating with disease severity and diversity.

  • 4

    Most bacteria in HS lesions originate from the patient's skin flora, with some secondary invaders contributing to the condition.

  • 5

    Hypergammaglobulinemia is common in HS patients and correlates with disease severity, indicating a potential immune response to bacteria.

Original Source(s)

Is hidradenitis suppurativa more an autoinfection than pure autoinflammation?

  • by Maïa Delage, Olivier Join-Lambert, Snaigune Miskinyte, Alain Hovnanian, Aude Nassif

  • July 6, 2026

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