Multi-omics integration reveals BPGM downregulation and potential plasma metabolite biomarkers for childhood asthma - Takeaways - MDSpire

Multi-omics integration reveals BPGM downregulation and potential plasma metabolite biomarkers for childhood asthma

  • By

  • Junlin Zhao

  • Zhiyuan Wang

  • Yanan Wang

  • Qianqian Dai

  • Menghua Li

  • Aliya Maimaitiniyazi

  • Zhenzhen Guo

  • Liang Ru

  • May 7, 2026

  • 0 min

Share

  • 1

    The study integrated transcriptomics and metabolomics to identify biomarkers and therapeutic targets in pediatric asthma.

  • 2

    BPGM downregulation was significantly associated with metabolic changes in the glycine-serine-threonine pathway.

  • 3

    516 differential metabolites were identified, with 5-aminolevulinic acid showing optimal diagnostic accuracy for asthma.

  • 4

    5-aminolevulinic acid correlated positively with serum IgE and eosinophil counts, indicating its potential as a biomarker.

  • 5

    The findings suggest a hypothetical link between BPGM expression changes and metabolic alterations in childhood asthma.

Original Source(s)

Multi-omics integration reveals BPGM downregulation and potential plasma metabolite biomarkers for childhood asthma

  • by Junlin Zhao, Zhiyuan Wang, Yanan Wang, Qianqian Dai, Menghua Li, Aliya Maimaitiniyazi, Zhenzhen Guo, Liang Ru

  • May 7, 2026

Related Content

Partly intraoperative cell salvage in pediatric craniocerebral trauma: effects on coagulation function, allogeneic blood requirements, and clinical outcomes — a propensity score-matched retrospective cohort study

Isoflurane for difficult sedation in critically ill children: a retrospective analysis in a mixed pediatric intensive care population

Usefulness of ultrasound in diagnosing constipation in children: a narrative review