Age, Multidomain Lifestyle Intervention, and White Matter Integrity: Secondary Analysis of the POINTER - Takeaways - MDSpire

Age, Multidomain Lifestyle Intervention, and White Matter Integrity: Secondary Analysis of the POINTER

  • By

  • Pauline Maillard

  • Prashanthi Vemuri

  • Danielle J. Harvey

  • Theresa M. Harrison

  • Ashritha L. Reddy

  • Hwamee Oh

  • Stephen Salloway

  • Simin Mahinrad

  • Thomas M. Holland

  • Rachel Whitmer

  • Mark A. Espeland

  • Laura D. Baker

  • Susan M. Landau

  • Charles DeCarli

  • July 13, 2026

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  • 1

    The POINTER study investigates the effects of multidomain lifestyle interventions on white matter integrity in older adults at risk for cognitive decline.

  • 2

    Cerebrovascular pathologies, including white matter hyperintensity and microstructural damage, significantly contribute to cognitive impairment in late life.

  • 3

    The study analyzes MRI outcomes to assess the impact of structured versus self-guided interventions on white matter injury and small vessel disease.

  • 4

    Participants aged 60 to 79 years were selected based on specific risk factors and were cognitively unimpaired but at risk for decline.

  • 5

    The POINTER Imaging study aims to identify individuals at higher risk for lesion progression using diffusion MRI measures.

Original Source(s)

Age, Multidomain Lifestyle Intervention, and White Matter Integrity: Secondary Analysis of the POINTER

  • by Pauline Maillard, Prashanthi Vemuri, Danielle J. Harvey, Theresa M. Harrison, Ashritha L. Reddy, Hwamee Oh, Stephen Salloway, Simin Mahinrad, Thomas M. Holland, Rachel Whitmer, Mark A. Espeland, Laura D. Baker, Susan M. Landau, Charles DeCarli

  • July 13, 2026

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