Pulmonary surveillance in inborn errors of immunity: current challenges and emerging approaches - Takeaways - MDSpire
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Monitoring Lung Health in Genetic Immune Disorders: Ongoing Challenges and New Strategies

  • By

  • Ernest Hoptioncann

  • Rachel L. Eddy

  • Catherine M. Biggs

  • Jonathan H. Rayment

  • May 20, 2026

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  • 1

    Inborn errors of immunity (IEIs) lead to significant pulmonary complications, affecting nearly 40% of individuals with these disorders.

  • 2

    Pulmonary complications are a major cause of mortality in IEIs, accounting for 17.4% of deaths, particularly in conditions like common variable immunodeficiency.

  • 3

    Recurrent infections and immune dysregulation are primary drivers of pulmonary complications in individuals with IEIs.

  • 4

    Emerging techniques like multiple-breath washout and pulmonary MRI provide radiation-free assessments for monitoring lung health in IEIs.

  • 5

    Effective management of pulmonary complications in IEIs requires sensitive tools for detection, monitoring, and treatment response assessment.

Original Source(s)

Pulmonary surveillance in inborn errors of immunity: current challenges and emerging approaches

  • by Ernest Hoptioncann, Rachel L. Eddy, Catherine M. Biggs, Jonathan H. Rayment

  • May 20, 2026

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