Case Report: Pediatric nasopharyngeal carcinoma masquerading as benign lymphadenopathy: diagnostic pitfalls in two cases - Takeaways - MDSpire

Case Report: Pediatric nasopharyngeal carcinoma masquerading as benign lymphadenopathy: diagnostic pitfalls in two cases

  • By

  • Yuhan Qiu

  • Yan Cheng

  • Aiqin Lin

  • Hui Li

  • Jie Liu

  • Wei Zhang

  • June 16, 2026

  • 0 min

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  • 1

    Pediatric nasopharyngeal carcinoma (NPC) is rare, accounting for less than 1% of pediatric malignancies, leading to diagnostic delays.

  • 2

    Two cases of pediatric NPC were misdiagnosed as benign lymphoproliferative disorders, highlighting diagnostic challenges.

  • 3

    Both patients underwent multimodal chemoradiotherapy and are currently under follow-up.

  • 4

    Persistent cervical lymphadenopathy in children necessitates early biopsy and specific immunohistochemical studies for accurate diagnosis.

  • 5

    Pediatric NPC is primarily the EBV-driven non-keratinizing subtype, differing biologically from adult NPC.

Original Source(s)

Case Report: Pediatric nasopharyngeal carcinoma masquerading as benign lymphadenopathy: diagnostic pitfalls in two cases

  • by Yuhan Qiu, Yan Cheng, Aiqin Lin, Hui Li, Jie Liu, Wei Zhang

  • June 16, 2026

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